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QKI-7 Monoclonal Antibody (N183/15)
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FIGURE: 1 / 5
QKI-7 Antibody (75-200) in IHC (F)
Double immunofluorescence revealing pruned Lewy Neurites (pSyn, Red) and the cytoplasms of mature mouse OLs (QKI-7, cat. 75-200, 1:500; green) at the level of the anterior commissure of a mouse 6 months after the intrastriatal injection of alpha--Syn PFFs. Horizontal brain section. Nuclei are counterstained with DRAQ7 (white). Image from publication CC-BY-4.0. PMID:36830639.
Product Details
75-200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N183/15
Immunogen
Synthetic peptide amino acids 303-317 of human QKI-7 (accession number Q96PU8-5).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: LEWIEMPVMP DISAH
Target Information
QKI-7 is an isoform of the Quaking (QKI) protein, which belongs to the STAR (Signal Transduction and Activation of RNA) family of RNA-binding proteins. QKI proteins play essential roles in RNA metabolism, including RNA splicing, stabilization, and translation, and are crucial for various cellular processes. QKI-7 is an important RNA-binding protein with significant roles in the nervous system, particularly in the regulation of myelination and neuronal RNA processing. Its study is essential for understanding the molecular basis of various neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; KH domain-containing RNA-binding protein QKI; lethal, Chr 17, U Wisconsin 1; MqkI; Protein quaking; QKI-5 protein; QKI/LOC100132735 fusion; quaking; quaking homolog, KH domain RNA binding; QUAKING-3; RNA binding protein HQK; unnamed protein product
Gene Aliases: 1110003F05Rik; 1500005P18; HKQ; Hqk; hqkI; l(17)-1Wis; l17Wis1; QK; QK1; QK3; QKI
UniProt ID: (Human) Q96PU8, (Mouse) Q9QYS9
Entrez Gene ID: (Human) 9444, (Mouse) 19317
vasculogenesis
mRNA processing
regulation of translation
spermatid development
intracellular mRNA localization
axon ensheathment
RNA splicing
positive regulation of gene expression
regulation of epithelial to mesenchymal transition
microglia differentiation
negative regulation of angiogenesis
negative regulation of translation
cell differentiation
positive regulation of myelination
negative regulation of type I interferon production
stress granule assembly
vascular smooth muscle cell differentiation
myelination
long-chain fatty acid biosynthetic process
positive regulation of cholesterol biosynthetic process
regulation of macrophage differentiation
negative regulation of macrophage differentiation
positive regulation of transcription, DNA-templated
regulation of mRNA splicing, via spliceosome
mRNA stabilization
regulation of astrocyte differentiation
positive regulation of oligodendrocyte differentiation
mRNA transport
regulation of cell development
negative regulation of cold-induced thermogenesis
spliceosome-depend formation of circular RNA
negative regulation of 3'-UTR-mediated mRNA stabilization
myofibroblast contraction
regulation of multicellular organismal development
negative regulation of miRNA catabolic process
transport
multicellular organism development
muscle cell differentiation
3'-UTR-mediated mRNA destabilization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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