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Gs Protein/Alpha Subunit Monoclonal Antibody (N192/12)
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Product Details
75-211
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N192/12
Immunogen
Fusion protein amino acids 1-380 (full-length, short form) of bovine Gs protein alpha subunit (accession number P04896-2) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylate cyclase-stimulating G alpha protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein alpha subunit; G-alpha-8; GNAS; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; gnas {ECO:0000312|RGD:2716}; Gs alpha subunit; GTP-binding regulatory protein (G-s-alpha).; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide binding protein alpha s; guanine nucleotide-binding protein G(s) subunit alpha isoforms; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G-s, alpha subunit; MGC33735; NESP55; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; stimulatory G-protein alpha subunit; unnamed protein product; XLalphas; XLas
Gene Aliases: 5530400H20Rik; A930027G11Rik; C130027O20Rik; Galphas; GNAS; GNAS1; Gnasxl; Gnpas; GPSA; Gsa; GSP; MNCb-5546; Nesp; NESP55; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6
UniProt ID: (Bovine) P04896, (Mouse) Q6R0H7, (Rat) P63095
Entrez Gene ID: (Bovine) 281793, (Mouse) 14683, (Rat) 24896
GTP binding
adenylate cyclase activator activity
metal ion binding
nucleotide binding
G-protein alpha-subunit binding
GTPase activity
signal transducer activity
insulin-like growth factor receptor binding
protein binding
guanyl nucleotide binding
protein domain specific binding
G-protein beta-subunit binding
G-protein beta/gamma-subunit complex binding
beta-2 adrenergic receptor binding
D1 dopamine receptor binding
mu-type opioid receptor binding
ionotropic glutamate receptor binding
alpha-tubulin binding
corticotropin-releasing hormone receptor 1 binding
heterotrimeric G-protein
adenylate cyclase-activating G-protein coupled receptor signaling pathway
negative regulation of multicellular organism growth
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
response to parathyroid hormone
adenylate cyclase-activating adrenergic receptor signaling pathway
skeletal system development
tissue homeostasis
positive regulation of protein phosphorylation
endochondral ossification
energy reserve metabolic process
DNA methylation
regulation of transcription from RNA polymerase II promoter
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
sensory perception of chemical stimulus
post-embryonic development
regulation of signal transduction
positive regulation of sodium ion transport
positive regulation of cAMP biosynthetic process
embryonic hindlimb morphogenesis
multicellular organism growth
negative regulation of renal sodium excretion
post-embryonic body morphogenesis
response to drug
skin development
positive regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
negative regulation of blood pressure
developmental growth
embryonic cranial skeleton morphogenesis
cognition
cartilage development
calcium ion homeostasis
bone development
hair follicle placode formation
platelet aggregation
cellular response to prostaglandin E stimulus
genetic imprinting
cellular response to catecholamine stimulus
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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