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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31)

View all (5) Neuregulin-CRD antibodies

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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31)

Product Details

75-226

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

N126B/31

Immunogen

Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

Neuregulin-CRD refers to the cysteine-rich domain (CRD) of neuregulins, a family of signaling proteins involved in various cellular processes, including growth, differentiation, and development. The cysteine-rich domain is critical for the interaction of neuregulins with their receptors, such as the ErbB family of receptor tyrosine kinases, facilitating the activation of downstream signaling pathways. This domain plays a vital role in the proper functioning of neuregulins in the nervous system, heart, and other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; unnamed protein product

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Gene Aliases: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297

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Entrez Gene ID: (Human) 3084, (Rat) 112400

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Function(s)
transcription cofactor activity receptor binding cytokine activity integrin binding protein binding growth factor activity zinc ion binding nickel cation binding protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity receptor agonist activity ErbB-2 class receptor binding growth factor
Process(es)
ventricular trabecula myocardium morphogenesis cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development brain development peripheral nervous system development cell proliferation positive regulation of cell proliferation regulation of cell communication negative regulation of cardiac muscle cell apoptotic process neural crest cell development regulation of signaling cell differentiation positive regulation of cell growth mammary gland development positive regulation of protein complex assembly activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB3 signaling pathway ERBB4 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway wound healing positive regulation of cell adhesion negative regulation of transcription, DNA-templated negative chemotaxis negative regulation of secretion positive regulation of developmental process positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation regulation of biological quality positive regulation of ERK1 and ERK2 cascade regulation of postsynaptic neurotransmitter receptor internalization positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade cell morphogenesis cardiac conduction system development activation of transmembrane receptor protein tyrosine kinase activity synapse assembly heart development muscle organ development locomotory behavior regulation of blood pressure glial cell differentiation glucose transport cell migration glial cell fate commitment negative regulation of protein catabolic process myelination regulation of protein heterodimerization activity cellular protein complex disassembly neurotransmitter receptor metabolic process regulation of cell differentiation positive regulation of protein kinase activity positive regulation of Ras protein signal transduction animal organ development neuron fate commitment positive regulation of protein kinase B signaling positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cardiac muscle cell differentiation
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