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Neuregulin-CRD (Cysteine-Rich Domain/Type III) Monoclonal Antibody (N126B/31), FL550
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Product Details
75-226-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N126B/31
Immunogen
Fusion protein amino acids 1-75 (membrane-associated N-terminus) of human Neuregulin-1 (accession number Q96IB3) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Neuregulin-CRD refers to the cysteine-rich domain (CRD) of neuregulins, a family of signaling proteins involved in various cellular processes, including growth, differentiation, and development. The cysteine-rich domain is critical for the interaction of neuregulins with their receptors, such as the ErbB family of receptor tyrosine kinases, facilitating the activation of downstream signaling pathways. This domain plays a vital role in the proper functioning of neuregulins in the nervous system, heart, and other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; unnamed protein product
Gene Aliases: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297
Entrez Gene ID: (Human) 3084, (Rat) 112400
transcription cofactor activity
receptor binding
cytokine activity
integrin binding
protein binding
growth factor activity
zinc ion binding
nickel cation binding
protein tyrosine kinase activator activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
receptor agonist activity
ErbB-2 class receptor binding
growth factor
ventricular trabecula myocardium morphogenesis
cell communication
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
brain development
peripheral nervous system development
cell proliferation
positive regulation of cell proliferation
regulation of cell communication
negative regulation of cardiac muscle cell apoptotic process
neural crest cell development
regulation of signaling
cell differentiation
positive regulation of cell growth
mammary gland development
positive regulation of protein complex assembly
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
ERBB3 signaling pathway
ERBB4 signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB2-ERBB4 signaling pathway
ERBB4-ERBB4 signaling pathway
wound healing
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
negative chemotaxis
negative regulation of secretion
positive regulation of developmental process
positive regulation of striated muscle cell differentiation
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
regulation of biological quality
positive regulation of ERK1 and ERK2 cascade
regulation of postsynaptic neurotransmitter receptor internalization
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
MAPK cascade
cell morphogenesis
cardiac conduction system development
activation of transmembrane receptor protein tyrosine kinase activity
synapse assembly
heart development
muscle organ development
locomotory behavior
regulation of blood pressure
glial cell differentiation
glucose transport
cell migration
glial cell fate commitment
negative regulation of protein catabolic process
myelination
regulation of protein heterodimerization activity
cellular protein complex disassembly
neurotransmitter receptor metabolic process
regulation of cell differentiation
positive regulation of protein kinase activity
positive regulation of Ras protein signal transduction
animal organ development
neuron fate commitment
positive regulation of protein kinase B signaling
positive regulation of protein tyrosine kinase activity
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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