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GluN1/NR1 Glutamate Receptor Monoclonal Antibody (N308/48)
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FIGURE: 1 / 5
GluN1/NR1 Glutamate Receptor Antibody (75-272) in IHC (F)
Representative fluorescence images of Fbxo2 (green) and NR1 (red; cat. 75-272, 1:500) fluorescence intensity in PFC slices from WT or Tau mice treated with Smyd3 inhibitor BCI121 or vehicle. Image from publication CC-BY-4.0. PMID:36609445.
Product Details
75-272
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N308/48
Immunogen
Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1 (accession number P35439) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; putative NMDtranscript(altAcc_e2); RP11-350O14.1
Gene Aliases: DEE101; GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; hNR1; M100174; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174
UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438
Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810
beta-amyloid binding
NMDA glutamate receptor activity
ion channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
ligand-gated ion channel activity
ligand-gated sodium channel activity
glycine binding
glutamate binding
glutamate-gated calcium ion channel activity
signaling receptor activity
macromolecular complex binding
metal ion binding
glycine-gated cation channel activity
ionotropic glutamate receptor activity
receptor binding
extracellular-glutamate-gated ion channel activity
cation channel activity
enzyme binding
voltage-gated cation channel activity
glutamate receptor binding
neurotransmitter binding
protein heterodimerization activity
protein dimerization activity
receptor activity
transmembrane signal receptor
ion transport
cation transport
chemical synaptic transmission
brain development
visual learning
positive regulation of calcium ion transport into cytosol
propylene metabolic process
calcium-mediated signaling
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
sodium ion transmembrane transport
regulation of membrane potential
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
protein heterotetramerization
positive regulation of synaptic transmission, glutamatergic
calcium ion homeostasis
excitatory postsynaptic potential
calcium ion transmembrane transport
calcium ion transmembrane import into cytosol
cation transmembrane transport
excitatory chemical synaptic transmission
positive regulation of reactive oxygen species biosynthetic process
regulation of cation transmembrane transport
cellular response to beta-amyloid
response to glycine
positive regulation of excitatory postsynaptic potential
conditioned taste aversion
startle response
suckling behavior
response to amphetamine
calcium ion transport
cellular calcium ion homeostasis
respiratory gaseous exchange
learning or memory
learning
memory
long-term memory
associative learning
adult locomotory behavior
olfactory learning
regulation of cell communication
positive regulation of cell death
response to organic cyclic compound
response to amine
sensory perception of pain
pons maturation
cerebral cortex development
regulation of ion transmembrane transport
social behavior
synaptic transmission, glutamatergic
positive regulation of apoptotic process
response to morphine
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
regulation of long-term neuronal synaptic plasticity
rhythmic process
regulation of dendrite morphogenesis
regulation of axonogenesis
neuromuscular process
protein tetramerization
response to calcium ion
regulation of synapse assembly
prepulse inhibition
male mating behavior
response to fungicide
cellular response to manganese ion
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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