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Antibodies Inc
Kv1.2 Potassium Channel Subunit Monoclonal Antibody (L76/36)
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Product Details
75-314
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
L76/36
Immunogen
Fusion protein amino acids 428-499 of human Kv1.2 (accession number P16389) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: QYLQVTSCPK IPSSPDLKKS RSASTISKSD YMEIQEGVNN SNEDFREENL KTANCTLANT NYVNITKMLT DV
Target Information
Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MK2; NGK1; Potassium (K+) channel protein alpha 2, voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 2; potassium voltage gated channel shaker related subfamily member 2; Potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RAK; RBK2; RCK5; RP11-284N8.1; unnamed protein product; Voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; Voltage-gated potassium channel subunit Kv1.2
Gene Aliases: Akr6a4; BK2; DEE32; EIEE32; ENSMUSG00000074335; Gm10672; HBK5; HK4; HUKIV; Kca1-2; KCNA2; KV1.2; Mk-2; MK2; NGK1; RBK2
UniProt ID: (Human) P16389, (Mouse) P63141, (Rat) P63142
Entrez Gene ID: (Human) 3737, (Mouse) 16490, (Rat) 25468
ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
protein binding
outward rectifier potassium channel activity
kinesin binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
voltage-gated ion channel activity
voltage-gated ion channel
action potential
ion transport
potassium ion transport
regulation of dopamine secretion
neuronal action potential
sensory perception of pain
optic nerve development
optic nerve structural organization
cerebral cortex development
corpus callosum development
ion transmembrane transport
regulation of circadian sleep/wake cycle, non-REM sleep
protein homooligomerization
transmembrane transport
regulation of postsynaptic membrane potential
potassium ion transmembrane transport
potassium ion export across plasma membrane
regulation of presynaptic membrane potential
transport
regulation of ion transmembrane transport
protein oligomerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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