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Antibodies Inc
NrCAM Monoclonal Antibody (N343/26), FL550
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Product Details
75-325-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N343/26
Immunogen
Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM (accession number Q810U4) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ankyrin-binding cell adhesion molecule NrCAM; mBravo; MGC138845; MGC138846; neuron-glia-CAM-related cell adhesion molecule; Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr CAM; Nr-CAM; rBravo
Gene Aliases: Bravo; C030017F07Rik; C130076O07Rik; Kiaa0343; mKIAA0343; Nrcam
UniProt ID: (Mouse) Q810U4
Entrez Gene ID: (Mouse) 319504, (Rat) 497815
cell adhesion
axon guidance
central nervous system development
protein localization
regulation of neuron projection development
single organismal cell-cell adhesion
neuronal action potential propagation
retinal ganglion cell axon guidance
heterotypic cell-cell adhesion
clustering of voltage-gated sodium channels
angiogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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