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Antibodies Inc
GABA-A-R-Alpha6 Monoclonal Antibody (N229A/32), FL550
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Product Details
75-388-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N229A/32
Immunogen
Fusion protein amino acids 325-420 (last cytoplasmic domain before extracellular C-terminus) of mouse GABA-A-R-Alpha6 (accession number P16305) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit alpha-6; GABA-A receptor alpha-6 subunit; GABAAR alpha6; GABAAR subunit alpha-6; GABRA 6; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
Gene Aliases: alpha6; GABA-ARalpha6; Gabra-6; Gabra6
UniProt ID: (Mouse) P16305, (Rat) P30191
Entrez Gene ID: (Mouse) 14399, (Rat) 29708
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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