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WRN Monoclonal Antibody (N428/12)
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Product Details
75-423
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N428/12
Immunogen
Fusion protein amino acids 38-236 (exonuclease domain) of human WRN (accession number Q14191) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; DKFZp686C2056; DNA helicase, RecQ-like type 3; exonuclease WRN; RecQ protein-like 2; similar to Werner syndrome helicase homolog; Werner syndrome ATP-dependent helicase; Werner syndrome protein; Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like; WRN
Gene Aliases: RECQ3; RECQL2; RECQL3; WRN
UniProt ID: (Human) Q14191
Entrez Gene ID: (Rat) 290805, (Human) 7486
magnesium ion binding
Y-form DNA binding
bubble DNA binding
nucleic acid binding
DNA binding
DNA helicase activity
ATP-dependent DNA helicase activity
helicase activity
exonuclease activity
ATP binding
3'-5' exonuclease activity
four-way junction helicase activity
ATPase activity
manganese ion binding
protein complex binding
protein homodimerization activity
3'-5' DNA helicase activity
ATP-dependent 3'-5' DNA helicase activity
G-quadruplex DNA binding
nucleotide binding
four-way junction DNA binding
catalytic activity
nuclease activity
protein binding
hydrolase activity
isomerase activity
MutLalpha complex binding
macromolecular complex binding
metal ion binding
forked DNA-dependent helicase activity
telomeric D-loop binding
telomeric G-quadruplex DNA binding
3'-flap-structured DNA binding
catalytic activity, acting on DNA
8-hydroxy-2'-deoxyguanosine DNA binding
DNA helicase
telomere maintenance
DNA synthesis involved in DNA repair
replicative cell aging
DNA metabolic process
DNA replication
DNA repair
base-excision repair
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
response to oxidative stress
cell aging
cellular response to starvation
response to UV-C
multicellular organism aging
replication fork processing
nucleolus to nucleoplasm transport
DNA duplex unwinding
regulation of growth rate
regulation of apoptotic process
positive regulation of hydrolase activity
cellular response to gamma radiation
nucleic acid phosphodiester bond hydrolysis
double-strand break repair via homologous recombination
nucleobase-containing compound metabolic process
mismatch repair
determination of adult lifespan
telomere maintenance via semi-conservative replication
DNA geometric change
telomeric D-loop disassembly
cellular senescence
replicative senescence
t-circle formation
positive regulation of strand invasion
protein localization to nucleolus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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