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TALK1 Potassium Channel Monoclonal Antibody (N466/14), FL650
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Product Details
75-461-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N466/14
Immunogen
Fusion protein amino acids 42-94 (first extracellular loop) and 259-292 (cytoplasmic C-terminus) of mouse TALK1 (accession number G5E845) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The KCNK16 gene encodes the TALK-1 channel, an abundant K+ channel transcript found in mouse and in human Beta-cells. There are four human TALK-1 transcript variants, including two that form functional K+ channels (TALK-1a (transcript variant 2) and TALK1-b (transcript variant 3). The TALK-1 structure includes 4 transmembrane domains, 2 extracellular loops, and intracellular N- and C-termini. The C-terminal tail of TALK-1 is a critical component that influences the magnitude of TALK-1 channel activation, while the N-terminus is important for protein interaction. TALK-1, two-pore domain K+ (K2p 16.1) channel is responsible for modulating glucose stimulated insulin secretion that relies on Beta-cell CA2+ influx. The channel produces outwardly rectifying, non-inactivating K+ currents, which are enhanced by elevations in extracellular pH. TALK-1 is thus pH-sensitive, with increased activity under alkaline conditions. In addition, it can be activated by singlet oxygen and nitric oxide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2P domain potassium channel Talk-1; Potassium channel subfamily K member 16; Potassium channel, subfamily K, member 16; TALK-1; TWIK-related alkaline pH-activated K(+) channel 1
Gene Aliases: 4731413G05Rik; Kcnk16; TALK-1; TALK1
UniProt ID: (Mouse) G5E845
Entrez Gene ID: (Mouse) 74571, (Rat) 688996
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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