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Proteintech
PRDX3 Recombinant Rabbit Monoclonal Antibody (1L11)
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Product Details
81833-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1L11
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTI KPSPAASKEY FQKVNQ
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anti-oxidant protein 1; antioxidant protein; Antioxidant protein 1; AOP-1; epididymis secretory sperm binding protein; HBC189; mitochondrial thioredoxin dependent peroxide reductase; mitochondrial Trx dependent peroxide reductase; Perioredoxin-3; Peroxiredoxin III; Peroxiredoxin-3; PRDX3; Protein MER5; Protein MER5 homolog; Prx; Prx 3; PRX III; PRX-3; Prx-III; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3; unnamed protein product
Gene Aliases: AOP-1; AOP1; AW822249; D0Tohi1; Ef2l; HBC189; MER5; PPPCD; PRDX3; PRO1748; prx-III; Prx3; SCAR32; SP-22; SP22; TDXM
UniProt ID: (Human) P30048, (Mouse) P20108, (Rat) Q9Z0V6
Entrez Gene ID: (Human) 10935, (Mouse) 11757, (Rat) 64371
peroxidase activity
protein binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
protein kinase binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxiredoxin activity
NADH-dependent peroxiredoxin activity
thioredoxin-dependent peroxiredoxin activity
protein C-terminus binding
kinase binding
molecular_function
peroxidase
maternal placenta development
response to oxidative stress
mitochondrion organization
positive regulation of cell proliferation
myeloid cell differentiation
response to lipopolysaccharide
negative regulation of kinase activity
cellular response to oxidative stress
cellular response to reactive oxygen species
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
cell redox homeostasis
positive regulation of NF-kappaB transcription factor activity
regulation of mitochondrial membrane potential
cellular oxidant detoxification
apoptotic process
peptidyl-cysteine oxidation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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