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Proteintech
PRDX3 Recombinant Rabbit Monoclonal Antibody (1L11), CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-81833
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1L11
Immunogen
PRDX3 fusion protein Ag1062
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAAAVGRLL RASVARHVSA IPWGISATAA LRPAACGRTS LTNLLCSGSS QAKLFSTSSS CHAPAVTQHA PYFKGTAVVN GEFKDLSLDD FKGKYLVLFF YPLDFTFVCP TEIVAFSDKA NEFHDVNCEV VAVSVDSHFS HLAWINTPRK NGGLGHMNIA LLSDLTKQIS RDYGVLLEGS GLALRGLFII DPNGVIKHLS VNDLPVGRSV EETLRLVKAF QYVETHGEVC PANWTPDSPT IKPSPAASKE YFQKVNQ
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anti-oxidant protein 1; antioxidant protein; Antioxidant protein 1; AOP-1; HBC189; mitochondrial thioredoxin dependent peroxide reductase; mitochondrial Trx dependent peroxide reductase; Perioredoxin-3; Peroxiredoxin III; Peroxiredoxin-3; Protein MER5; Protein MER5 homolog; Prx; Prx 3; PRX III; PRX-3; Prx-III; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3
Gene Aliases: AOP1; AW822249; D0Tohi1; Ef2l; Mer5; PRDX3; Prx3; SP22; TDXM
UniProt ID: (Mouse) P20108, (Rat) Q9Z0V6
Entrez Gene ID: (Mouse) 11757, (Rat) 64371
peroxidase activity
protein C-terminus binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
kinase binding
protein kinase binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxiredoxin activity
molecular_function
peroxidase
maternal placenta development
apoptotic process
response to oxidative stress
mitochondrion organization
positive regulation of cell proliferation
peptidyl-cysteine oxidation
myeloid cell differentiation
response to lipopolysaccharide
negative regulation of kinase activity
cellular response to oxidative stress
cellular response to reactive oxygen species
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
positive regulation of NF-kappaB transcription factor activity
regulation of mitochondrial membrane potential
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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