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Proteintech
AF9 Polyclonal Antibody
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Product Details
12825-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AF9 Fusion Protein Ag3528 (1-348 aa encoded by BC036089)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASSCAVQV KLELGHRAQV RKKPTVEGFT HDWMVFVRGP EHSNIQHFVE KVVFHLHESF PRPKRVCKDP PYKVEESGYA GFILPIEVYF KNKEEPRKVR FDYDLFLHLE GHPPVNHLRC EKLTFNNPTE DFRRKLLKAG GDPNRSIHTS SSSSSSSSSS SSSSSSSSSS SSSGSSSSSS SSSSSSSSSS STSFSKPHKL MKEHKEKPSK DSREHKSAFK EPSRDHNKSS KESSKKPKEN KPLKEEKIVP KMAFKEPKPM SKEPKPDSNL LTITSGQDKK APSKRPPISD SEELSAKKRK KSSSEALFKS FSSAPPLILT CSADKKQIKD KSHVKMGKVK IESETSEKK (1-348 aa encoded by BC036089 )
Target Information
The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9;11)(p22;q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AF-9; AF-9 protein; ALL1-fused gene from chromosome 9 protein; KMT2A/MLLT3 fusion protein; myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 3 isoform MLLT3_1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 3 isoform MLLT3_3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog; myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia; translocated to 3; Protein AF-9; translocated to, 3; unnamed protein product; YEATS domain-containing protein 3
Gene Aliases: 2210011H10Rik; 2610012I03Rik; 3830408D16Rik; Af-9; AF9; D4Ertd321e; MLLT3; YEATS3
UniProt ID: (Human) P42568, (Mouse) A2AM29
Entrez Gene ID: (Human) 4300, (Mouse) 70122, (Rat) 114510
chromatin organization
segment specification
anterior/posterior pattern specification
gene expression
positive regulation of transcription, DNA-templated
hematopoietic stem cell differentiation
negative regulation of canonical Wnt signaling pathway
regulation of chromatin organization
regulation of stem cell division
positive regulation of Wnt signaling pathway, planar cell polarity pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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