|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 351 of Human ANGPTL3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Contains||0.025% Proclin 300|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28058 targets ANGPTL3 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-28058 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 351 of Human ANGPTL3.
The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ANG-5; angiopoietin 5; Angiopoietin-5; angiopoietin-like 3; Angiopoietin-like protein 3; Angiopoietin-related protein 3; ANGPT5; FHBL2
Gene Aliases: ANG-5; ANGPT5; ANGPTL3; ANL3; FHBL2; UNQ153/PRO179
UniProt ID: (Human) Q9Y5C1
Entrez Gene ID: (Human) 27329
Molecular Function: signaling molecule
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