Proteintech

ARX Polyclonal Antibody

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Questions & Answers

Questions & Answers

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ARX Antibody in Western Blot (WB) — NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 20739-1-AP ( ARX Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

ARX Antibody in Western Blot (WB) — SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20739-1-AP (ARX Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

ARX Antibody in Western Blot (WB) — NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 20739-1-AP (ARX Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

ARX Antibody in Western Blot (WB) — NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 20739-1-AP (ARX Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

ARX Antibody in Western Blot (WB) — SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20739-1-AP (ARX Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

20739-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:200-1:1,000	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Conjugate	Unconjugated
Form	Liquid
Concentration	0.28 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

The antibody is specific to ARX. This is a rabbit polyclonal antibody raised against a peptide mapping within human ARX.

Target Information

Arx contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This protein is thought to be involved in CNS development. Mutations in the Arx gene cause X-linked mental retardation and epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aristaless-related homeobox; aristaless-related homeobox, X-linked; cancer/testis antigen 121; Homeobox protein ARX

Gene Aliases: ARX; CT121; EIEE1; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRX76; MRX87; MRXS1; PRTS

UniProt ID: (Human) Q96QS3, (Mouse) O35085

Entrez Gene ID: (Human) 170302, (Mouse) 11878

Molecular Function: homeodomain transcription factor

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated axon guidance positive regulation of gene expression globus pallidus development cerebral cortex tangential migration embryonic olfactory bulb interneuron precursor migration cell proliferation in forebrain cerebral cortex GABAergic interneuron migration regulation of cell proliferation lipid digestion positive regulation of organ growth epithelial cell fate commitment

Process(es)

RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding chromatin binding