Arx contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This protein is thought to be involved in CNS development. Mutations in the Arx gene cause X-linked mental retardation and epilepsy.
Aristaless-related homeobox; aristaless-related homeobox, X-linked; Arx; cancer/testis antigen 121; Homeobox protein ARX