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Invitrogen
ARX Polyclonal Antibody
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FIGURE: 1 / 3
ARX Antibody (PA5-47896) in ICC/IF
Immunocytochemistry analysis of ARX in immersion fixed U‚87 MG human glioblastoma/astrocytoma cell line. Samples were incubated in ARX polyclonal antibody (Product # PA5-47896) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei.
Product Details
PA5-47896
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human ARX Ser2-Ala100
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Arx contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This protein is thought to be involved in CNS development. Mutations in the Arx gene cause X-linked mental retardation and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aristaless-related homeobox; aristaless-related homeobox, X-linked; cancer/testis antigen 121; Homeobox protein ARX
Gene Aliases: ARX; CT121; EIEE1; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRX76; MRX87; MRXS1; PRTS
UniProt ID: (Human) Q96QS3
Entrez Gene ID: (Human) 170302
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
protein binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
axon guidance
positive regulation of gene expression
globus pallidus development
olfactory bulb development
cerebral cortex tangential migration
embryonic olfactory bulb interneuron precursor migration
cell proliferation in forebrain
cerebral cortex GABAergic interneuron migration
cell differentiation
forebrain development
organ growth
lipid digestion
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
neuron fate commitment
neuron development
regulation of epithelial cell proliferation
epithelial cell fate commitment
interneuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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