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Phospho-c-Fos (Ser374) Polyclonal Antibody, Alexa Fluor™ 680

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Phospho-c-Fos (Ser374) Polyclonal Antibody, Alexa Fluor™ 680

Product Details

BS-12911R-A680

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Ser374
3D Epitope / Immunogen

Conjugate

Alexa Fluor™ 680 Alexa Fluor™ 680 Alexa Fluor™ 680

Excitation/Emission Max

681/704 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activator protein 1; c-fos oncogene; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; FOS; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Protein c-Fos; Proto-oncogene c-Fos; proto-oncogene cFOS; proto-oncogene protein c-fos; Transcription factor AP-1 subunit c-Fos; unnamed protein product; v-fos FBJ murine osteosarcoma viral oncogene homolog

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Gene Aliases: AP-1; C-FOS; cFos; D12Rfj1; FOS; G0S7; p55

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UniProt ID: (Human) P01100, (Mouse) P01101, (Rat) P12841

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Entrez Gene ID: (Human) 2353, (Mouse) 14281, (Rat) 314322

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding macromolecular complex binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding transcription regulatory region DNA binding protein heterodimerization activity basic leucine zipper transcription factor
Process(es)
conditioned taste aversion neural retina development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response transforming growth factor beta receptor signaling pathway nervous system development female pregnancy response to xenobiotic stimulus response to light stimulus response to mechanical stimulus response to gravity response to toxic substance regulation of gene expression response to activity skeletal muscle cell proliferation cerebral cortex development neuron differentiation osteoclast differentiation response to lipopolysaccharide response to progesterone response to insulin cellular response to hormone stimulus response to cytokine cellular response to zinc ion starvation cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation response to muscle stretch response to ethanol positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone response to corticosterone myoblast proliferation response to cAMP SMAD protein signal transduction cellular response to calcium ion cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to parathyroid hormone stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus medium-term memory integrated stress response signaling positive regulation of pri-miRNA transcription from RNA polymerase II promoter mononuclear cell differentiation response to forskolin cellular response to phorbol 13-acetate 12-myristate cellular response to prolactin cellular response to extracellular stimulus response to drug aging response to cold response to organic cyclic compound sleep
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