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Proteintech
BubR1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-11504
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BubR1 fusion protein Ag2053
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: QSPWCSQYR RQLLKSLPEL SASAELCIED RPMPKLEIEK EIELGNEDYC IKREYLICED YKLFWVAPRN SAELTVIKVS SQPVPWDFYI NLKLKERLNE DFDHFCSCYQ YQDGCIVWHQ YINCFTLQDL LQHSEYITHE ITVLIIYNLL TIVEMLHKAE IVHGDLSPRC LILRNRIHDP YDCNKNNQAL KIVDFSYSVD LRVQLDVFTL SGFRTVQILE GQKILANCSS PYQVDLFGIA DLAHLLLFKE HLQVFWDGSF WKLSQNISEL KDGELWNKFF VRILNANDEA TVSVLGELAA EMNGVFDTTF QSHLNKALWK VGKLTSPGAL LFQ
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BUB1B, mitotic checkpoint serine/threonine kinase; BubR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog beta; hBub1; hBUBR1; MAD3/BUB1-related protein kinase; Mitotic checkpoint kinase MAD3L; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Protein SSK1
Gene Aliases: AU045529; Bub1A; BUB1B; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1
UniProt ID: (Human) O60566, (Mouse) Q9Z1S0
Entrez Gene ID: (Human) 701, (Mouse) 12236
protein phosphorylation
apoptotic process
sister chromatid cohesion
mitotic nuclear division
metaphase/anaphase transition of mitotic cell cycle
mitotic cell cycle checkpoint
mitotic spindle assembly checkpoint
cell proliferation
anaphase-promoting complex-dependent catabolic process
protein localization to kinetochore
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
cell cycle
phosphorylation
protein localization to chromosome, centromeric region
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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