Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcium uniporter regulatory subunit MCUb, mitochondrial; CCDC109B; coiled-coil domain containing 109B; Coiled-coil domain-containing protein 109B; MCUb; mitochondrial calcium uniporter regulatory subunit MCUb
Gene Aliases: CCDC109B; MCUB
UniProt ID: (Human) Q9NWR8
Entrez Gene ID: (Human) 55013