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CCDC109B Antibody (PA5-61817)
Relative expression in different tissues in IHC: Detection of differential expression levels of CCDC109B demonstrates antibody specificity. Immunohistochemical analysis of CCDC109B using anti-CCDC109B Polyclonal Antibody (Product # PA5-61817), shows significant staining of CCDC109B in human tonsil and shows minimal or weak staining in human kidney tissues. The relative expression levels of CCDC109B within ... View More
Product Details
PA5-61817
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCDC109B. Recombinant protein control fragment (Product #RP-101087).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2639359
Product Specific Information
Immunogen sequence: SNEHTAEMEH MKSLVHRLFT ILHLEESQKK REHHLLEKID HLKEQLQPLE QVKAGIEAHS E
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.
Target Information
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium uniporter regulatory subunit MCUb, mitochondrial; coiled-coil domain containing 109B; Coiled-coil domain-containing protein 109B; MCUb; mitochondrial calcium uniporter regulatory subunit MCUb
Gene Aliases: CCDC109B; MCUB
UniProt ID: (Human) Q9NWR8
Entrez Gene ID: (Human) 55013
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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