Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.
CD13 (ANPEP) is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. CD13 is a metalloprotease that preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 also has a role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is expressed by granulocytes, monocytes, myeloid leukemia cells, and is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas. CD13 functions as an aminopeptidase enzyme and is also alpha receptor for coronavirus.
Analyte Specific Reagent
Protein Aliases: alanyl (membrane) aminopeptidase; alanyl aminopeptidase; aminopeptidase M; aminopeptidase N; aminopeptidase N/CD13; AP-M; AP-N; Apn; Cd13; hAPN; membrane alanyl aminopeptidase; membrane protein p161; microsomal aminopeptidase; myeloid plasma membrane glycoprotein CD13; P150
Gene Aliases: APN; CD13; GP150; LAP1; P150; PEPN
Entrez Gene ID: (Human) 290