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Invitrogen
CD34 Monoclonal Antibody (581), PE
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FIGURE: 1 / 9
CD34 Antibody (CD34-581-04) in Flow
Nature communications 2024 -
Mutation-induced MDS HSCs' transcriptional reprogramming overcomes venetoclax-based therapy vulnerability. a Schematic of UPN#1's clinical course. After HMA therapy failure (cycle 0 [C0]), UPN#1 received 5-azacitidine (75 mg/m 2 for 5 days) and venetoclax (400 mg/m 2 for 14 days) every month. The patient had mCR at cycle 2 (C2); however, after the venetoclax dose was reduced to 100 mg/m 2 , the patient had ... View More
Product Details
CD34-581-04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
581
Immunogen
Human CD34.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS with 10% sucrose, 4mg/mL BSA
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD34; CD34 antigen; CD34 sialomucin; glycoprotein expressed in lymphohematopoietic progenitor cells; Hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2; unnamed protein product
Gene Aliases: CD34
UniProt ID: (Human) P28906
Entrez Gene ID: (Human) 947
tissue homeostasis
endothelial cell proliferation
glomerular filtration
endothelium development
cell adhesion
cell-matrix adhesion
signal transduction
positive regulation of gene expression
negative regulation of gene expression
hemopoiesis
negative regulation of interleukin-2 production
mesangial cell-matrix adhesion
paracrine signaling
positive regulation of odontogenesis
positive regulation of angiogenesis
cell motility
leukocyte migration
transdifferentiation
vascular wound healing
hematopoietic stem cell proliferation
positive regulation of granulocyte colony-stimulating factor production
extracellular exosome assembly
glomerular endothelium development
stem cell proliferation
metanephric glomerular mesangial cell differentiation
cell-cell adhesion
positive regulation of vasculogenesis
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