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Proteintech

CD71 Polyclonal Antibody

View all (173) Transferrin Receptor (CD71) antibodies

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CD71 Polyclonal Antibody

Product Details

32333-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:16,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD71 fusion protein Eg1064
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

500 µg/mL

Amount

75 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Sequence of this protein is as follows: CKRVEQKEEC VKLAETEETD KSETMETEDV PTSSRLYWAD LKTLLSEKLN SIEFADTIKQ LSQNTYTPRE AGSQKDESLA YYIENQFHEF KFSKVWRDEH YVKIQVKSSI GQNMVTIVQS NGNLDPVESP EGYVAFSKPT EVSGKLVHAN FGTKKDFEEL SYSVNGSLVI VRAGEITFAE KVANAQSFNA IGVLIYMDKN KFPVVEADLA LFGHAHLGTG DPYTPGFPSF NHTQFPPSQS SGLPNIPVQT ISRAAAEKLF GKMEGSCPAR WNIDSSCKLE LSQNQNVKLI VKNVLKERRI LNIFGVIKGY EEPDRYVVVG AQRDALGAGV AAKSSVGTGL LLKLAQVFSD MISKDGFRPS RSIIFASWTA GDFGAVGATE WLEGYLSSLH LKAFTYINLD KVVLGTSNFK VSASPLLYTL MGKIMQDVKH PVDGKSLYRD SNWISKVEKL SFDNAAYPFL AYSGIPAVSF CFCEDADYPY LGTRLDTYEA LTQKVPQLNQ MVRTAAEVAG QLIIKLTHDV ELNLDYEMYN SKLLSFMKDL NQFKTDIRDM GLSLQWLYSA RGDYFRATSR LTTDFHNAEK TNRFVMREIN DRIMKVEYHF LSPYVSPRES PFRHIFWGSG SHTLSALVEN LKLRQKNITA FNETLFRNQL ALATWTIQGV ANALSGDIWN IDNEF

Target Information

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD antigen CD71; CD71; mammary tumor virus receptor 1; p90; T9; TR; transferrin receptor; Transferrin receptor 1; Transferrin receptor protein 1; unnamed protein product

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Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR

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UniProt ID: (Human) Q1HE24, (Mouse) Q62351

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Entrez Gene ID: (Human) 7037, (Mouse) 22042

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Function(s)
virus receptor activity RNA binding double-stranded RNA binding transferrin receptor activity protein binding protein kinase binding Hsp70 protein binding identical protein binding protein homodimerization activity macromolecular complex binding chaperone binding glycoprotein binding iron ion transmembrane transporter activity transferrin transmembrane transporter activity poly(A) RNA binding metalloprotease
Process(es)
regulation of cell growth response to hypoxia iron ion transport cellular iron ion homeostasis endocytosis receptor-mediated endocytosis acute-phase response signal transduction cell surface receptor signaling pathway response to nutrient response to iron ion response to manganese ion positive regulation of gene expression negative regulation of mitochondrial fusion osteoclast differentiation positive regulation of B cell proliferation positive regulation of protein complex assembly receptor internalization response to retinoic acid transferrin transport intracellular signal transduction positive regulation of T cell proliferation regulation of cell proliferation negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of isotype switching response to copper ion viral entry into host cell multicellular organismal iron ion homeostasis cellular response to xenobiotic stimulus regulation of postsynaptic membrane neurotransmitter receptor levels transport across blood-brain barrier positive regulation of protein localization to nucleus cellular response to leukemia inhibitory factor iron ion transmembrane transport cellular response to drug positive regulation of bone resorption protein transmembrane transport iron ion import
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