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|Tested species reactivity||Human|
|Published species reactivity||Human , Rhesus monkey|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||PBS with BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
The R-phycoerythrin (PE)-Texas Red® conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
This antibody recognizes the alpha chain alone as well as the alpha/beta heterodimer.
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD38 (T10) is a single chain 46 kDa type II integral glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor.
Analyte Specific Reagent
Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice.
MHCD0817 was used in flow cytometry to study the role of plasmacytoid dendritic cells in human immunodeficiency virus type 1 infection and pathogenesis
|Li G,Cheng M,Nunoya J,Cheng L,Guo H,Yu H,Liu YJ,Su L,Zhang L||PLoS pathogens (10:null)||2014|
|Rhesus monkey||Not Cited||
Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV.
MHCD0817 was used in flow cytometry to examine HIV/SIV-derived peptide vaccines.
|Pahar B,Cantu MA,Zhao W,Kuroda MJ,Veazey RS,Montefiori DC,Clements JD,Aye PP,Lackner AA,Lovgren-Bengtsson K,Sestak K||Vaccine (24:6839)||2006|
CD8 antigen, alpha polypeptide (p32), Leu2 T-lymphocyte antigen, OKT8 T-cell antigen, T cell co-receptor, T-cell antigen Leu2, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, T8 T-cell antigen, CD8 antigen, beta polypeptide 1 (p37), T lymphocyte surface glycoprotein beta chain, T-cell surface glycoprotein CD8 beta chain, CD8, Leu-2, MAL, CD8a, CD8b, CD8alpha, CD8beta
Leu2, LEU2, P37, CD8, LY3, MAL, CD8B1, p32, LYT3
Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Immunity and defense T-cell mediated immunity MHCI-mediated immunity Other receptor mediated signaling pathway