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Stat5a Monoclonal Antibody (OTI4H1), TrueMAB™

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Stat5a Monoclonal Antibody (OTI4H1), TrueMAB™

Product Details

CF500006

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI4H1

Immunogen

Human recombinant protein fragment corresponding to amino acids 2-104 of human Stat5a produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; Mammary gland factor; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; STAT; STAT5B; unnamed protein product

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Gene Aliases: MGF; STAT5; STAT5A

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UniProt ID: (Human) P42229, (Rat) Q62771

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Entrez Gene ID: (Human) 6776, (Rat) 24918

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding phosphate ion binding sequence-specific DNA binding DNA-binding transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding double-stranded DNA binding signal transducer activity protein phosphatase binding DNA-binding transcription factor
Process(es)
mitotic cell cycle luteinization natural killer cell differentiation positive regulation of endothelial cell proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade female pregnancy lactation cell proliferation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage lymphocyte differentiation regulation of cell adhesion B cell differentiation erythrocyte differentiation eosinophil differentiation regulation of epithelial cell differentiation mammary gland development positive regulation of interleukin-2 production positive regulation of natural killer cell differentiation mast cell apoptotic process negative regulation of mast cell apoptotic process myeloid cell apoptotic process negative regulation of myeloid cell apoptotic process T cell differentiation in thymus interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway reelin-mediated signaling pathway interleukin-5-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway interleukin-3-mediated signaling pathway thrombopoietin-mediated signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell proliferation natural killer cell mediated cytotoxicity gamma-delta T cell differentiation T cell homeostasis response to peptide hormone positive regulation of blood vessel endothelial cell migration positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development positive regulation of inflammatory response activated T cell proliferation mast cell differentiation positive regulation of mast cell differentiation JAK-STAT cascade involved in growth hormone signaling pathway prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development mast cell proliferation positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus regulation of hemopoiesis negative regulation of T-helper 17 cell lineage commitment allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process peptidyl-tyrosine phosphorylation response to nutrient levels prolactin signaling pathway negative regulation of apoptotic process positive regulation of interleukin-2 biosynthetic process response to ethanol creatinine metabolic process multicellular organismal reproductive process mammary gland involution
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