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OriGene
STAT5A Monoclonal Antibody (OTI4H1), Biotin, TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
TA700170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4H1
Immunogen
Human recombinant protein fragment corresponding to amino acids 2-104 of human Stat5a produced in E.coli.
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 10mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; STAT; STAT5B; unnamed protein product
Gene Aliases: MGF; STAT5
UniProt ID: (Human) P42229
Entrez Gene ID: (Human) 6776
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
phosphate ion binding
sequence-specific DNA binding
DNA-binding transcription factor binding
promoter-specific chromatin binding
positive regulation of endothelial cell proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
signal transduction
JAK-STAT cascade
cytokine-mediated signaling pathway
taurine metabolic process
eosinophil differentiation
interleukin-15-mediated signaling pathway
interleukin-4-mediated signaling pathway
reelin-mediated signaling pathway
interleukin-5-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
interleukin-3-mediated signaling pathway
thrombopoietin-mediated signaling pathway
regulation of multicellular organism growth
regulation of cell proliferation
response to peptide hormone
positive regulation of blood vessel endothelial cell migration
positive regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade involved in growth hormone signaling pathway
regulation of hemopoiesis
negative regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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