Recommended positive controls: Drosophila melanogaster (adult wild type), Cisd2 over express (actin promoter).
Predicted reactivity: Drosophila (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
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Protein Aliases: CDGSH iron-sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2 homolog; CG1458-PA; Cisd2-PA; Endoplasmic reticulum intermembrane small protein; Miner1; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Nutrient-deprivation autophagy factor-1; RE49709p; RH38554p; zinc finger, CDGSH-type domain 2
Gene Aliases: BcDNA:RE49709; CDGSH2; CG1458; CISD2; Dmel\CG1458; Dmel_CG1458; dWFS2; ERIS; Miner1; MitoNEET; NAF-1; WFS2; ZCD2