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Invitrogen
CISD2 Polyclonal Antibody
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Product Details
PA5-31955
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length Drosophila CG1458 Recombinant protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Drosophila melanogaster (adult wild type), Cisd2 over express (actin promoter).
Predicted reactivity: Drosophila (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDGSH iron-sulfur domain protein; CDGSH iron-sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein-2 homolog; CG1458-PA; Cisd2-PA; Endoplasmic reticulum intermembrane small protein; Miner1; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Nutrient-deprivation autophagy factor-1; RE49709p; RH38554p; unnamed protein product; zinc finger, CDGSH-type domain 2
Gene Aliases: BcDNA:RE49709; CDGSH2; CG1458; Cisd; CISD2; Dmel\CG1458; Dmel_CG1458; dWFS2; ERIS; Miner1; MitoNEET; NAF-1; WFS2; ZCD2
UniProt ID: (Human) Q8N5K1, (Fruit fly) Q9VAM6
Entrez Gene ID: (Human) 493856, (Fruit fly) 43459
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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