Search
Proteintech
AIRE Monoclonal Antibody (1A3C3), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL488-66262
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A3C3
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: QKNEDECAVC RDGGELICCD GCPRAFHLAC LSPPLREIPS GTWRCSSCLQ ATVQEVQPRA EEPRPQEPPV ETPLPPGLRS AGEEVRGPPG EPLAGMDTTL VYKHLPAPPS AAPLPGLDSS ALHPLLCVGP EGQQNLAPGA RCGVCGDGTD VLRCTHCAAA FHWRCHFPAG TSRPGTGLRC RSCSGDVTPA PVEGVLAPSP ARLAPGPAKD DTASHEPALH RDDLESLLSE HTFDGILQWA IQSMARPAAP FPS
Target Information
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: AIRE protein; APECED protein; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune regulator; OTTHUMP00000109529
Gene Aliases: AIRE; AIRE1; APECED; APS1; APSI; PGA1
UniProt ID: (Human) O43918
Entrez Gene ID: (Pig) 100621659, (Human) 326
peripheral T cell tolerance induction
tolerance induction
central tolerance induction to self antigen
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of translation
immune response
humoral immune response
positive regulation of chemokine production
negative thymic T cell selection
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus epithelium morphogenesis
regulation of thymocyte migration
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support