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Proteintech

STXBP1 Monoclonal Antibody (1B5B3), CoraLite® Plus 488

View all (20) MUNC18 antibodies

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Product Details

CL488-67137

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1B5B3

Immunogen

STXBP1 fusion protein Ag28605

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: HELTFQAMS YDLLPIENDV YKYETSGIGE ARVKEVLLDE DDDLWIALRH KHIAEVSQEV TRSLKDFSSS KRMNTGEKTT MRDLSQMLKK MPQYQKELSK YSTHLHLAED CMKHYQGTVD KLCRVEQDLA MGTDAEGEKI KDPMRAIVPI LLDANVSTYD KIRIILLYIF LKNGITEENL NKLIQHAQIP PEDSEIITNM AHLGVPIVTD STLRRRSKPE RKERISEQTY QLSRWTPIIK DIMEDTIEDK LDTKHYPYIS TRSSASFSTT AVSARYGHWH KNKAPGEYRS GPRLIIFILG GVSLNEMRCA YEVTQANGKW EVLIGSTHIL TPQKLLDTLK KLNKTDEEIS S

Target Information

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; UNC-18 homolog; unc-18-1; Unc-18A; Unc18-1; unnamed protein product

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Gene Aliases: AI317162; AI326233; ANC18HA; DEE4; MMS10-G; Ms10g; Munc-18a; MUNC18-1; N-Sec1; NSEC1; NSEC1A; P67; Rb-sec1; RBSEC1; rbSec1A; rbSec1B; Sec1; STXBP1; Sxtbp1; unc-18A; UNC18; Unc18-1; UNC18A; Unc18h

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UniProt ID: (Human) P61764, (Mouse) O08599, (Rat) P61765

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Entrez Gene ID: (Human) 6812, (Mouse) 20910, (Rat) 25558

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Function(s)
SNARE binding RNA binding protein binding syntaxin-1 binding protein kinase binding protein domain specific binding syntaxin binding identical protein binding phospholipase binding poly(A) RNA binding protein N-terminus binding membrane trafficking regulatory protein
Process(es)
platelet degranulation developmental process involved in reproduction intracellular protein transport exocytosis vesicle docking involved in exocytosis neurotransmitter secretion neuromuscular synaptic transmission axon target recognition regulation of synaptic vesicle priming protein transport synaptic vesicle priming synaptic vesicle maturation vesicle-mediated transport negative regulation of protein complex assembly regulation of vesicle fusion regulation of synaptic vesicle fusion to presynaptic membrane negative regulation of synaptic transmission, GABAergic response to estradiol SNARE complex assembly regulation of SNARE complex assembly positive regulation of mast cell degranulation negative regulation of neuron apoptotic process regulated exocytosis positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis protein stabilization neuron apoptotic process establishment of localization in cell long term synaptic depression platelet aggregation cellular response to interferon-gamma protein localization to plasma membrane presynaptic dense core vesicle exocytosis positive regulation of vesicle docking positive regulation of glutamate secretion, neurotransmission regulation of regulated secretory pathway regulation of acrosomal vesicle exocytosis transport synaptic vesicle fusion to presynaptic active zone membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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