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Proteintech
PIAS1 Recombinant Rabbit Monoclonal Antibody (1C22), CoraLite® Plus 488
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Product Details
CL488-82873-2
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1C22
Immunogen
PIAS1 fusion protein Ag18132
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: PSAKRTCPSL SPTSPLNNKG ILSLPHQASP VSRTPSLPAV DTSYINTSLI QDYRHPFHMT PMPYDLQGLD FFPFLSGDNQ HYNTSLLAAA AAAVSDDQDL LHSSRFFPYT SSQMFLDQLS AGGSTSLPTT NGSSSGSNSS LVSSNSLRES HSHTVTNRSS TDTASIFGII PDIISLD
Target Information
PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AR interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; Gu binding protein; Gu-binding protein; nuclear protein that binds to nucleolar RNA helicase Gu protein and to p53; PIAS1/GBP; PIG23; Protein inhibitor of activated STAT protein 1; RING-type E3 ubiquitin transferase PIAS1; RNA helicase II-binding protein; unnamed protein product; zinc finger, MIZ-type containing 3
Gene Aliases: 2900068C24Rik; DDXBP1; GBP; GU/RH-II; PIAS1; ZMIZ3
UniProt ID: (Human) O75925, (Mouse) O88907
Entrez Gene ID: (Human) 8554, (Mouse) 56469
transcription regulatory region sequence-specific DNA binding
DNA binding
transcription cofactor activity
transcription corepressor activity
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
metal ion binding
SUMO ligase activity
DNA-binding transcription factor binding
protein C-terminus binding
transcription factor binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
JAK-STAT cascade
protein sumoylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of smooth muscle cell differentiation
protein-DNA complex assembly
negative regulation of nucleic acid-templated transcription
double-strand break repair via homologous recombination
DNA double-strand break processing
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
spermatogenesis
visual learning
regulation of macromolecule metabolic process
positive regulation of protein localization to cell periphery
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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