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Proteintech
RORA Recombinant Rabbit Monoclonal Antibody (230217G6), CoraLite® Plus 488
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Product Details
CL488-82930
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230217G6
Immunogen
RORA fusion protein Ag0944
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LDIQPSPDQS GLDINGIKPE PICDYTPASG FFPYCSFTNG ETSPTVSMAE LEHLAQNISK SHLETCQYLR EELQQITWQT FLQEEIENYQ NKQREVMWQL CAIKITEAIQ YVVEFAKRID GFMELCQNDQ IVLLKAGSLE VVFIRMCRAF DSQNNTVYFD GKYASPDVFK SLGCEDFISF VFEFGKSLCS MHLTEDEIAL FSAFVLMSAD RSWLQEKVKI EKLQQKIQLA LQHVLQKNHR EDGILTKLIC KVSTLRALCG RHTEKLMAFK AIYPDIVRLH FPPLYKELFT SEFEPAMQID G
Target Information
RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; putative new variant; RAR-related orphan nuclear receptor alpha; RAR-related orphan receptor A; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; retinoid-related orphan receptor alpha; Retinoid-related orphan receptor-alpha; ROR Alpha; ROR-alpha; Roralpha; transcription factor RZR-alpha
Gene Aliases: IDDECA; NR1F1; ROR1; ROR2; ROR3; RORA; RORa1; RORalpha; RZR-ALPHA; RZRA
UniProt ID: (Human) P35398
Entrez Gene ID: (Human) 6095, (Rat) 300807
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcription corepressor binding
transcription coactivator binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
core promoter sequence-specific DNA binding
steroid hormone receptor activity
transcription factor binding
C4 zinc finger nuclear receptor
angiogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
xenobiotic metabolic process
nitric oxide biosynthetic process
circadian rhythm
regulation of smoothened signaling pathway
regulation of gene expression
positive regulation of vascular endothelial growth factor production
regulation of glucose metabolic process
regulation of steroid metabolic process
cerebellar Purkinje cell differentiation
cerebellar granule cell precursor proliferation
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
cholesterol homeostasis
muscle cell differentiation
regulation of circadian rhythm
positive regulation of circadian rhythm
regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cGMP metabolic process
rhythmic process
negative regulation of inflammatory response
triglyceride homeostasis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to hypoxia
T-helper 17 cell differentiation
transcription, DNA-templated
steroid hormone mediated signaling pathway
regulation of transcription involved in cell fate commitment
regulation of cholesterol homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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