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Proteintech
MLLT1 Recombinant Rabbit Monoclonal Antibody (230519E7), CoraLite® Plus 488
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Product Details
CL488-83242-3
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
230519E7
Immunogen
MLLT1 fusion protein Ag34210
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EFRYKLLRAG GVMVMPEGAD TVSRPSPDYP MLPTIPLSAF SDPKKTKPSH GSKDANKESS KTSKPHKVTK EHRERPRKDS ESKSSSKELE REQAKSSKDT SRKLGEGRLP KEEKAPPPKA AFKEPKMALK ETKLESTSPK GGPPPPPPPP PRASSKRPAT ADSPKPSAKK QKKSSSKGSR SAPGTSPRTS SSSSFSDKKP AKDKSSTRGE KVKAESEPRE AKKALEVEES NSEDEASFKS ESAQSSPSNS SSSSDSSSDS DFEPSQNHSQ GPLRSMVEDL QSEESDEDDS SSGEEAAGKT NPGRDSRLSF SDSESDNSAD SSLPSREPPP PQKPPPPNSK VSGRRSPESC S
Target Information
Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTC-503J8.6; Eleven-nineteen-leukeumia; ENL/MLL fusion; MLL/ENL fusion protein; MLLT1/MLL fusion; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; Protein ENL; translocated to HRX in t(11;19) leukemia; YEATS domain-containing protein 1
Gene Aliases: ENL; LTG19; MLLT1; YEATS1
UniProt ID: (Human) Q03111
Entrez Gene ID: (Human) 4298
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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