Search
Proteintech
DOCK8 Recombinant Rabbit Monoclonal Antibody (230441A2), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL488-83270-2
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
230441A2
Immunogen
DOCK8 fusion protein Ag34585
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: EVYKLVIPIL EAHREFRKLT LTHSKLQRAF DSIVNKDHKR MFGTYFRVGF FGSKFGDLDE QEFVYKEPAI TKLPEISHRL EAFYGQCFGA EFVEVIKDST PVDKTKLDPN KAYIQITFVE PYFDEYEMKD RVTYFEKNFN LRRFMYTTPF TLEGRPRGEL HEQYRRNTVL TTMHAFPYIK TRISVIQKEE FVLTPIEVAI EDMKKKTLQL AVAINQEPPD AKMLQMVLQG SVGATVNQGP LEVAQVFLAE IPADPKLYRH HNKLRLCFKE FIMRCGEAVE KNKRLITADQ REYQQELKKN YNKLKENLRP MIERKIPELY KPIFRVESQK RDSFHRSSFR KCETQLSQGS
Target Information
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 1200017A24Rik; Dedicator of cytokinesis protein 8; epididymis luminal protein 205; unnamed protein product
Gene Aliases: DOCK8; HEL-205; HIES2; MRD2; ZIR8
UniProt ID: (Human) Q8NF50
Entrez Gene ID: (Human) 81704
immunological synapse formation
small GTPase mediated signal transduction
regulation of Rho protein signal transduction
dendritic cell migration
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
memory T cell proliferation
negative regulation of T cell apoptotic process
positive regulation of establishment of T cell polarity
cellular response to chemokine
positive regulation of T cell migration
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support