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Proteintech
PSMD1 Recombinant Rabbit Monoclonal Antibody (240458C9), CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL488-83521-4
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240458C9
Immunogen
PSMD1 fusion protein Ag12009
Conjugate
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: AVSDVNDDVR RAAVESLGFI LFRTPEQCPS VVSLLSESYN PHVRYGAAMA LGICCAGTGN KEAINLLEPM TNDPVNYVRQ GALIASALIM IQQTEITCPK VNQFRQLYSK VINDKHDDVM AKFGAILAQG ILDAGGHNVT ISLQSRTGHT HMPSVVGVLV FTQFWFWFPL SHFLSLAYTP TCVIGLNKDL KMPKVQYKSN CKPSTFAYPA PLEVPKEKEK EKVSTAVLSI TAKAKKKEKE KEKKEEEKME VDEAEKKEEK EKKKEPEPNF QLLDNPARVM PAQLKVLTMP ETCRYQPFKP LSIGGIIILK DTSEDIEELV EPVAAHGPKI EEEEQEPEPP EPFEYIDD
Target Information
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S proteasome p112 subunit; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112; 26S proteasome, subunit p112; MGC133040; MGC133041; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; unnamed protein product
Gene Aliases: 2410026J11Rik; P112; Rpn2; S1
UniProt ID: (Human) Q99460, (Rat) O88761, (Mouse) Q3TXS7
Entrez Gene ID: (Human) 5707, (Rat) 83806, (Mouse) 70247
proteasomal protein catabolic process
regulation of protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
response to oxidative stress
regulation of proteasomal protein catabolic process
cellular response to type I interferon
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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