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Proteintech
Geminin Recombinant Rabbit Monoclonal Antibody (240835B5), CoraLite® Plus 488
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Product Details
CL488-84199-2
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240835B5
Immunogen
Geminin fusion protein Ag1076
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS SSTDAKPCI
Target Information
GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Geminin; Geminin GMNN; OTTHUMP00000039393; RP3 369A17.3; similar to Xenopus laevis geminin; unnamed protein product
Gene Aliases: Gem; GMNN; MGORS6
UniProt ID: (Human) O75496
Entrez Gene ID: (Human) 51053
regulation of DNA replication
regulation of mitotic cell cycle
negative regulation of DNA replication
organ morphogenesis
regulation of DNA-dependent DNA replication initiation
positive regulation of chromatin binding
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
protein-containing complex assembly
DNA replication preinitiation complex assembly
negative regulation of DNA-dependent DNA replication
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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