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PD-1/CD279 Monoclonal Antibody (J110), CoraLite® Plus 594
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FIGURE: 1 / 2
PD-1/CD279 Antibody (CL594-65119) in Flow
1x10^6 PHA treated (3 day) human PBMCs were surface stained with CL405 Anti-Human CD3 (CL405-65151, Clone: UCHT1) and 5 µL CoraLite® Plus 594 Anti-Human PD-1/CD279 (CL594-65119, Clone: J110) (right) or CoraLite®594 Mouse IgG1 Isotype Control (CL594-65124, Clone: MOPC-21) (left). 1x10^6 untreated human PBMCs were surface stained with CL405 Anti-Human CD3 (CL405-65151, Clone: UCHT1) and 5 µL CoraLite® Plus 594 Anti-Human PD-1/CD279 (CL594-65119, Clone: J110) (center). Cells were incubated with FC Receptor Block prior to staining. Cells were ... View More
Product Details
CL594-65119
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
J110
Immunogen
fusion protein
Conjugate
Excitation/Emission Max
588/604 nm
Form
Liquid
Concentration
5 µL/Test
Purification
Affinity chromatography
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD279; CD279; PD-1; hPD1; PD-1; PD1; alternatively spliced; PDCD1; programmed cell death 1 protein; Programmed cell death protein 1; Protein PD-1; Protein PD1; sCD279; soluble CD279; systemic lupus erythematosus susceptibility 2; unnamed protein product
Gene Aliases: AIMTBS; CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; PDCD1; SLEB2
UniProt ID: (Human) Q15116
Entrez Gene ID: (Human) 5133
B cell apoptotic process
adaptive immune response
immune system process
negative regulation of tolerance induction
negative regulation of T cell mediated immune response to tumor cell
negative regulation of B cell apoptotic process
apoptotic process
humoral immune response
regulation of immune response
negative regulation of immune response
negative regulation of T cell activation
negative regulation of multicellular organismal process
positive regulation of T cell apoptotic process
regulatory T cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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