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Proteintech
ANKRD1 Monoclonal Antibody (1F11F1), CoraLite® 594
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Product Details
CL594-67775
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1F11F1
Immunogen
ANKRD1 fusion protein Ag29974
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MMVLKVEELV TGKKNGNGEA GEFLPEDFRD GEYEAAVTLE KQEDLKTLLA HPVTLGEQQW KSEKQREAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYR KTKVPVVKEP EPEIITEPVD VPTFLKAALE NKLPVVEKFL SDKNNPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWASRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LIMYGADLNI KNCAGKTPMD LVLHWQNGTK AIFDSLRENS YKTSRIATF
Target Information
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; Cardiac adriamycin-responsive protein; Cardiac ankyrin repeat protein; cardiac responsive adriamycin protein; CARP; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; epididymis secretory sperm binding protein; liver ankyrin repeat domain 1; muscle ankyrin repeat protein; unnamed protein product
Gene Aliases: ALRP; ANKRD1; bA320F15.2; C-193; C193; CARP; Crap; CVARP; HA1A2; MARP; MARP1; MCARP
UniProt ID: (Rabbit) Q9TU71, (Pig) Q865U8, (Human) Q15327, (Mouse) Q9CR42, (Rat) Q8R560
Entrez Gene ID: (Rabbit) 100008719, (Pig) 396959, (Human) 27063, (Mouse) 107765, (Rat) 27064
p53 binding
DNA binding
transcription cofactor activity
transcription coactivator activity
transcription corepressor activity
protein binding
titin binding
histone deacetylase binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
R-SMAD binding
RNA polymerase II transcription factor binding
RNA polymerase II transcription coactivator activity
transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of neuron projection development
cellular response to drug
skeletal muscle cell differentiation
response to muscle stretch
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein secretion
cardiac muscle tissue morphogenesis
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to transforming growth factor beta stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of DNA biosynthetic process
muscle cell differentiation
negative regulation of transcription, DNA-templated
cellular response to organic cyclic compound
cellular response to hypoxia
sarcomere organization
positive regulation of transcription, DNA-templated
cellular response to xenobiotic stimulus
phospholipase C/protein kinase C signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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