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TLR3/CD283 Recombinant Rabbit Monoclonal Antibody (230445G9), CoraLite® Plus 594

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TLR3/CD283 Recombinant Rabbit Monoclonal Antibody (230445G9), CoraLite® Plus 594

Product Details

CL594-98016-2

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

230445G9

Immunogen

TLR3/CD283 fusion protein Ag34044
View immunogen

Conjugate

CoraLite® Plus 594 CoraLite® Plus 594 CoraLite® Plus 594

Excitation/Emission Max

588/604 nm

Form

Liquid

Concentration

5 µL/Test

Purification

Protein A

Storage buffer

PBS with 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: FEGWRISFYW NVSVHRVLGF KEIDRQTEQF EYAAYIIHAY KDKDWVWEHF SSMEKEDQSL KFCLEERDFE AGVFELEAIV NSIKRSRKII FVITHHLLKD PLCKRFKVHH AVQQAIEQNL DSIILVFLEE IPDYKLNHAL CLRRGMFKSH CILNWPVQKE RIGAFRHKLQ VALGSKNSVH

Target Information

TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD283; TLR 3; TLR3; Toll-like receptor 3; unnamed protein product

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Gene Aliases: CD283; IIAE2; IMD83; TLR3

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UniProt ID: (Human) O15455

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Entrez Gene ID: (Human) 7098

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Function(s)
RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding signaling receptor activity pattern recognition receptor activity identical protein binding ubiquitin-like protein ligase binding
Process(es)
MAPK cascade microglial cell activation toll-like receptor signaling pathway immune system process positive regulation of immune system process regulation of dendritic cell cytokine production defense response inflammatory response hyperosmotic response signal transduction activation of NF-kappaB-inducing kinase activity JNK cascade male gonad development detection of virus response to virus positive regulation of gene expression positive regulation of type I interferon production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 3 signaling pathway regulation of toll-like receptor 3 signaling pathway type III interferon production positive regulation of type III interferon production cellular response to interferon-beta defense response to bacterium positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process response to exogenous dsRNA response to dsRNA innate immune response negative regulation of osteoclast differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of inflammatory response defense response to virus positive regulation of macrophage cytokine production cellular response to mechanical stimulus cellular response to interferon-gamma cellular response to exogenous dsRNA cellular response to xenobiotic stimulus inflammatory response to wounding extrinsic apoptotic signaling pathway necroptotic signaling pathway cellular response to virus intracellular signaling cassette positive regulation of cytokine production involved in inflammatory response
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