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Proteintech
MICA/MICB Monoclonal Antibody (6D4), CoraLite® Plus 647
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Product Details
CL647-65161
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6D4
Immunogen
Transfected C1R cells expressing MICA
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell stress-regulated membrane protein; HLA class I antigen; ligand to the NKG2D receptor; major histocompatibility complex class I chain-related protein A; MHC class I antigen-related protein B; MHC class I chain-related protein A; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence A; MHC class I polypeptide-related sequence B; MHC class I related chain A; MHC class I related sequence A; MHC class I-like molecule PERB11.2-IMX; MIC-A; MIC-B; sMICA; sMICB; soluble MICA; soluble MICB; stress inducible class I homolog; unnamed protein product
Gene Aliases: MIC-A; MICA; MICB; PERB11.1; PERB11.2
UniProt ID: (Human) Q95IY7, (Human) Q29980
Entrez Gene ID: (Human) 100507436, (Human) 4277
T cell mediated cytotoxicity
adaptive immune response
immune system process
immune response to tumor cell
immune response
cellular response to DNA damage stimulus
signal transduction
response to heat
negative regulation of defense response
killing of cells of other organism
negative regulation of natural killer cell activation
natural killer cell mediated cytotoxicity
defense response to bacterium
negative regulation of natural killer cell mediated cytotoxicity
gamma-delta T cell activation
regulation of immune response
defense response to virus
immune response-activating cell surface receptor signaling pathway
response to oxidative stress
response to retinoic acid
negative regulation of defense response to virus by host
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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