Search

  • 訂單查詢
  • 快速訂購

Proteintech

CD85j/LILRB1 Monoclonal Antibody (GHI/75), CoraLite® Plus 647

View all (40) CD85j (ILT2) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

CL647-65238

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

GHI/75

Immunogen

Recombinant protein

Conjugate

CoraLite® Plus 647 CoraLite® Plus 647 CoraLite® Plus 647

Excitation/Emission Max

654/674 nm

Form

Liquid

Purification

Affinity chromatography

Storage buffer

PBS with 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Wet ice

Target Information

CD85j, also known as a member of the leukocyte immunoglobulin-like receptor (LIR) family, is a single transmembrane glycoprotein with a long cytoplasmic domain containing four immunoreceptor tyrosine-based inhibitory motifs (ITIMs). These motifs signal through interactions with SHP-1, transducing negative signals that inhibit immune response stimulation. CD85j is expressed on myeloid cells such as monocytes and dendritic cells, as well as on subsets of lymphoid cells including NK, T, and B cells. The expression of CD85j is correlated with leukemias such as acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). On CD8+ cells, CD85j expression is associated with effector cell function and plays a significant role in viral infections, including HIV, Epstein-Barr virus, and cytomegalovirus (CMV). CD85j binds to MHC class I molecules, including HLA-G, A, F, B27, E, and F, on antigen-presenting cells. The receptor helps control inflammatory responses and cytotoxicity, focusing the immune response and limiting autoreactivity. CD85j belongs to the subfamily B class of LIR receptors, which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and multiple transcript variants encoding different isoforms have been identified for this gene. Its gene is located in a cluster at chromosomal region 19q13.4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CD85 antigen-like family member J; CD85j; Ig-like transcript 2; ILT-2; ILT2a; allelic form of ILT2; ILT2b; alternatively spliced form of ILT2; ILT2c; alternatively spliced form of ILT2; immunoglobulin heavy chain variable region; Immunoglobulin-like transcript 2; leucocyte Ig-like receptor B1; Leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LIR-1; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7; unnamed protein product

View more View less

Gene Aliases: CD85J; ILT-2; ILT2; LILRB1; LIR-1; LIR1; MIR-7; MIR7; PIR-B; PIRB

View more View less

UniProt ID: (Human) Q8NHL6

View more View less

Entrez Gene ID: (Human) 10859

View more View less

Function(s)
beta-amyloid binding protein binding protein phosphatase 1 binding MHC class Ib protein complex binding MHC class Ib protein binding HLA-A specific inhibitory MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class I receptor activity MHC class Ib receptor activity inhibitory MHC class I receptor activity SH2 domain binding MHC class I protein binding protein homodimerization activity
Process(es)
negative regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host adaptive immune response T cell proliferation involved in immune response immune system process negative regulation of cytokine production involved in immune response immune response-regulating signaling pathway immune response-inhibiting cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway signal transduction cell surface receptor signaling pathway response to virus positive regulation of gene expression negative regulation of serotonin secretion receptor internalization negative regulation of interferon-beta production negative regulation of interferon-gamma production negative regulation of interleukin-10 production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production negative regulation of mononuclear cell proliferation negative regulation of T cell proliferation positive regulation of apoptotic process negative regulation of cell cycle negative regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter negative regulation of natural killer cell mediated cytotoxicity negative regulation of alpha-beta T cell activation defense response to virus negative regulation of calcium ion transport positive regulation of macrophage cytokine production cellular response to lipopolysaccharide negative regulation of transforming growth factor beta production dendritic cell differentiation interleukin-10-mediated signaling pathway negative regulation of dendritic cell apoptotic process negative regulation of CD8-positive, alpha-beta T cell activation negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of gamma-delta T cell activation involved in immune response negative regulation of dendritic cell differentiation negative regulation of osteoclast development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support