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Proteintech
CD85j/LILRB1 Monoclonal Antibody (GHI/75), Cardinal Red™
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Product Details
CR-65238
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
GHI/75
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
592/611 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
CD85j, also known as a member of the leukocyte immunoglobulin-like receptor (LIR) family, is a single transmembrane glycoprotein with a long cytoplasmic domain containing four immunoreceptor tyrosine-based inhibitory motifs (ITIMs). These motifs signal through interactions with SHP-1, transducing negative signals that inhibit immune response stimulation. CD85j is expressed on myeloid cells such as monocytes and dendritic cells, as well as on subsets of lymphoid cells including NK, T, and B cells. The expression of CD85j is correlated with leukemias such as acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). On CD8+ cells, CD85j expression is associated with effector cell function and plays a significant role in viral infections, including HIV, Epstein-Barr virus, and cytomegalovirus (CMV). CD85j binds to MHC class I molecules, including HLA-G, A, F, B27, E, and F, on antigen-presenting cells. The receptor helps control inflammatory responses and cytotoxicity, focusing the immune response and limiting autoreactivity. CD85j belongs to the subfamily B class of LIR receptors, which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and multiple transcript variants encoding different isoforms have been identified for this gene. Its gene is located in a cluster at chromosomal region 19q13.4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD85 antigen-like family member J; CD85j; Ig-like transcript 2; ILT-2; Immunoglobulin-like transcript 2; leucocyte Ig-like receptor B1; Leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LIR-1; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7
Gene Aliases: CD85J; ILT-2; ILT2; LILRB1; LIR-1; LIR1; MIR-7; MIR7; PIR-B; PIRB
UniProt ID: (Human) Q8NHL6
Entrez Gene ID: (Human) 10859
negative regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
adaptive immune response
T cell proliferation involved in immune response
negative regulation of cytokine secretion involved in immune response
immune response-inhibiting cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
signal transduction
response to virus
positive regulation of gene expression
negative regulation of serotonin secretion
receptor internalization
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of mononuclear cell proliferation
negative regulation of interferon-beta secretion
negative regulation of T cell proliferation
negative regulation of tumor necrosis factor biosynthetic process
positive regulation of apoptotic process
negative regulation of interferon-gamma biosynthetic process
negative regulation of cell cycle
negative regulation of endocytosis
positive regulation of cytolysis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of alpha-beta T cell activation
regulation of immune response
defense response to virus
negative regulation of calcium ion transport
cellular response to lipopolysaccharide
interferon-gamma secretion
dendritic cell differentiation
negative regulation of dendritic cell apoptotic process
negative regulation of interleukin-10 secretion
negative regulation of interleukin-12 secretion
negative regulation of CD8-positive, alpha-beta T cell activation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of gamma-delta T cell activation involved in immune response
negative regulation of dendritic cell differentiation
negative regulation of transforming growth factor-beta secretion
negative regulation of osteoclast development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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