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Proteintech
KAT2A/GCN5 Monoclonal Antibody (1F6G7), CoraLite® Plus 750
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Product Details
CL750-66575
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1F6G7
Immunogen
KAT2A/GCN5 fusion protein Ag6940
Conjugate
Excitation/Emission Max
755/780 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: EYIARLVFDP KHKTLALIKD GRVIGGICFR MFPTQGFTEI VFCAVTSNEQ VKGYGTHLMN HLKEYHIKHN ILYFLTYADE YAIGYFKKQG FSKDIKVPKS RYLGYIKDYE GATLMECELN PRIPYTELSH IIKKQKEIIK KLIERKQAQI RKVYPGLSCF KEGVRQIPVE SVPGIRETGW KPLGKEKGKE LKDPDQLYTT LKNLLAQIKS HPSAWPFMEP VKKSEAPDYY EVIRFPIDLK TMTERLRSRY YVTRKLFVAD LQRVIANCRE YNPPDSEYCR CASALEKFFY FKLKEGGLID K
Target Information
SAGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histoneacetylase complex which has Gcn5p as catalyst subunit and functions overlapping with the fundamental transcription factor TFIID which has Taf1p as catalyst subunit. However, SAGA and TFIID have different allotment and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). As its molecular function, there is the chemical modification of histone, or the recruitment by direct interaction of transcription regulating factor on DNA, or the control of transcription starting reaction by TBP. Gcn5p that show histoneacetylase activity is one kind of the above-mentioned Ada protein group, and in the case of budding yeast it is composed of 439 amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5 general control of amino acid synthesis-like 2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; General control of amino acid synthesis, yeast, homolog-like 2; general control of amino acid synthesis-like 2; hGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; histone acetyltransferase, GCN5 family; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KATA2; Lysine acetyltransferase 2A; MmGCN5; PCAF-B/GCN5; STAF97
Gene Aliases: 1110051E14Rik; AW212720; GCN5; GCN5L2; hGCN5; KAT2A; mmGCN5; PCAF-b
UniProt ID: (Human) Q92830, (Mouse) Q9JHD2
Entrez Gene ID: (Human) 2648, (Mouse) 14534, (Rat) 303539
chromatin binding
transcription coactivator activity
histone acetyltransferase activity
protein binding
N-acetyltransferase activity
H3 histone acetyltransferase activity
acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
protein phosphatase binding
histone deacetylase binding
histone acetyltransferase activity (H3-K9 specific)
histone acetyltransferase activity (H3-K18 specific)
histone acetyltransferase activity (H4-K12 specific)
peptide-lysine-N-acetyltransferase activity
histone succinyltransferase activity
peptide glutaryltransferase activity
histone glutaryltransferase activity
DNA-binding transcription factor binding
transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
somitogenesis
positive regulation of cytokine production
neural tube closure
gluconeogenesis
regulation of DNA repair
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
heart development
long-term memory
regulation of gene expression
internal peptidyl-lysine acetylation
telencephalon development
metencephalon development
midbrain development
positive regulation of cell projection organization
regulation of protein stability
response to nutrient levels
multicellular organism growth
protein modification process
regulation of RNA splicing
regulation of regulatory T cell differentiation
negative regulation of gluconeogenesis
positive regulation of gluconeogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
negative regulation of centriole replication
fibroblast proliferation
regulation of synaptic plasticity
intracellular distribution of mitochondria
regulation of T cell activation
regulation of cell division
regulation of cell cycle
limb development
regulation of cartilage development
regulation of small molecule metabolic process
cellular response to tumor necrosis factor
peptidyl-lysine glutarylation
regulation of bone development
cellular response to nerve growth factor stimulus
regulation of stem cell population maintenance
positive regulation of cardiac muscle cell differentiation
transcription, DNA-templated
cell proliferation
histone acetylation
histone deubiquitination
positive regulation of histone acetylation
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
histone H3 acetylation
histone H4-K12 acetylation
histone H3-K14 acetylation
cardiac muscle cell differentiation
alpha-tubulin acetylation
regulation of mitophagy
regulation of nucleic acid-templated transcription
positive regulation of protein targeting to mitochondrion
positive regulation of transcription regulatory region DNA binding
response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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