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Proteintech

KAT2A/GNC5 Monoclonal Antibody (1F6G7)

5 References
View all (12) GCN5 antibodies

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KAT2A/GNC5 Monoclonal Antibody (1F6G7)

Product Details

66575-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1F6G7

Immunogen

KAT2A/GNC5 Fusion Protein Ag6940 (537-837 aa encoded by BC032743)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EYIARLVFD PKHKTLALIK DGRVIGGICF RMFPTQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH NILYFLTYAD EYAIGYFKKQ GFSKDIKVPK SRYLGYIKDY EGATLMECEL NPRIPYTELS HIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKEGVRQIPV ESVPGIRETG WKPLGKEKGK ELKDPDQLYT TLKNLLAQIK SHPSAWPFME PVKKSEAPDY YEVIRFPIDL KTMTERLRSR YYVTRKLFVA DLQRVIANCR EYNPPDSEYC RCASALEKFF YFKLKEGGLI DK (537-837 aa encoded by BC032743)

Target Information

SAGA (Spt-Ada-Gen5 histone acetyltransferase complex) is a histoneacetylase complex which has Gcn5p as catalyst subunit and functions overlapping with the fundamental transcription factor TFIID which has Taf1p as catalyst subunit. However, SAGA and TFIID have different allotment and each accomplishes the important role in the transcription for Housekeeping gene group and Stress Responding gene group. Also, SAGA is a gigantic protein complex which is composed of Ada protein group (5 kinds), TBP related protein group (4 kinds), TAF protein group (5 kinds that also pertain to TFIID), and other protein groups (>6 kinds). As its molecular function, there is the chemical modification of histone, or the recruitment by direct interaction of transcription regulating factor on DNA, or the control of transcription starting reaction by TBP. Gcn5p that show histoneacetylase activity is one kind of the above-mentioned Ada protein group, and in the case of budding yeast it is composed of 439 amino acid residues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5 general control of amino acid synthesis-like 2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5-like 2; general control of amino acid synthesis, yeast homolog-like 2; General control of amino acid synthesis, yeast, homolog-like 2; general control of amino acid synthesis-like 2; hGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; histone acetyltransferase, GCN5 family; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KATA2; Lysine acetyltransferase 2A; MmGCN5; PCAF-B/GCN5; STAF97

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Gene Aliases: 1110051E14Rik; AW212720; GCN5; GCN5L2; hGCN5; KAT2A; mmGCN5; PCAF-b

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UniProt ID: (Human) Q92830, (Mouse) Q9JHD2

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Entrez Gene ID: (Human) 2648, (Mouse) 14534, (Rat) 303539

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Function(s)
chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding N-acetyltransferase activity H3 histone acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups protein phosphatase binding histone deacetylase binding histone acetyltransferase activity (H3-K9 specific) histone acetyltransferase activity (H3-K18 specific) histone acetyltransferase activity (H4-K12 specific) peptide-lysine-N-acetyltransferase activity histone succinyltransferase activity peptide glutaryltransferase activity histone glutaryltransferase activity DNA-binding transcription factor binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development somitogenesis positive regulation of cytokine production neural tube closure gluconeogenesis regulation of DNA repair chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development heart development long-term memory regulation of gene expression internal peptidyl-lysine acetylation telencephalon development metencephalon development midbrain development positive regulation of cell projection organization regulation of protein stability response to nutrient levels multicellular organism growth protein modification process regulation of RNA splicing regulation of regulatory T cell differentiation negative regulation of gluconeogenesis positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development negative regulation of centriole replication fibroblast proliferation regulation of synaptic plasticity intracellular distribution of mitochondria regulation of T cell activation regulation of cell division regulation of cell cycle limb development regulation of cartilage development regulation of small molecule metabolic process cellular response to tumor necrosis factor peptidyl-lysine glutarylation regulation of bone development cellular response to nerve growth factor stimulus regulation of stem cell population maintenance positive regulation of cardiac muscle cell differentiation transcription, DNA-templated cell proliferation histone acetylation histone deubiquitination positive regulation of histone acetylation positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter histone H3 acetylation histone H4-K12 acetylation histone H3-K14 acetylation cardiac muscle cell differentiation alpha-tubulin acetylation regulation of mitophagy regulation of nucleic acid-templated transcription positive regulation of protein targeting to mitochondrion positive regulation of transcription regulatory region DNA binding response to organic cyclic compound
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