Search
Proteintech
ATG5 Recombinant Rabbit Monoclonal Antibody (5M5), CoraLite® Plus 750
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL750-81803
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
5M5
Immunogen
ATG5 fusion protein Ag0214
Conjugate
Excitation/Emission Max
755/780 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process. ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation. Following conjugation to ATG12, the conjugate participates in the formation of autophagosome. ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton. Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alternatively spliced; APG 5; APG5 autophagy 5 like (APG5L); APG5 autophagy 5-like; APG5-like; Apoptosis-specific protein; Apoptosis-specific protein (ASP); ATG5 autophagy related 5 homolog; Autophagy protein 5; autophagy-related 5; similar to S. cerevisiae ATG5 autophagy related 5; unnamed protein product
Gene Aliases: 2010107M05Rik; 3110067M24Rik; APG5; APG5-LIKE; APG5L; ASP; ATG5; Atg5l; AW319544; C88337; hAPG5; Paddy; SCAR25
UniProt ID: (Human) Q9H1Y0, (Mouse) Q99J83, (Rat) Q3MQ06
Entrez Gene ID: (Human) 9474, (Mouse) 11793, (Rat) 365601
autophagosome assembly
mitophagy
blood vessel remodeling
immune system process
regulation of cytokine production involved in immune response
chromatin organization
autophagy
apoptotic process
cellular response to nitrogen starvation
cellular response to starvation
response to xenobiotic stimulus
response to fungus
response to iron(II) ion
positive regulation of autophagy
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
macroautophagy
protein ubiquitination
antigen processing and presentation of endogenous antigen
negative regulation of protein ubiquitination
negative regulation of type I interferon production
piecemeal microautophagy of nucleus
aggrephagy
negative stranded viral RNA replication
vasodilation
negative regulation of apoptotic process
negative regulation of programmed cell death
post-translational protein modification
negative thymic T cell selection
innate immune response
negative regulation of innate immune response
otolith development
negative regulation of defense response to virus
negative regulation of phagocytosis
regulation of release of sequestered calcium ion into cytosol
defense response to virus
establishment of localization in cell
ventricular cardiac muscle cell development
heart contraction
chaperone-mediated autophagy
positive regulation of stress granule assembly
mucus secretion
positive regulation of mucus secretion
cellular response to nitrosative stress
axonal transport
regulation of postsynaptic membrane neurotransmitter receptor levels
postsynaptic modulation of chemical synaptic transmission
regulation of autophagosome maturation
regulation of cilium assembly
response to fluoride
negative regulation of autophagic cell death
positive regulation of viral translation
regulation of reactive oxygen species metabolic process
mitophagy
regulation of cytokine secretion involved in immune response
C-terminal protein lipidation
response to drug
nucleophagy
positive regulation of mitophagy
negative regulation of reactive oxygen species metabolic process
negative regulation of histone H4-K16 acetylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support