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TIGIT Recombinant Rabbit Monoclonal Antibody (240242G1), CoraLite® Plus 750
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FIGURE: 1 / 2
TIGIT Antibody (CL750-98026) in Flow
1x10^6 anti-CD3/CD28 treated mouse splenocytes were surface stained with 0.25 µg CoraLite® Plus 750 Anti-Mouse TIGIT Rabbit Recombinant Antibody (CL750-98026, Clone: 240242G1) (red) or Isotype Control (blue). 1x10^6 untreated mouse splenocytes were stained with 0.25 µg CoraLite® Plus 750 Anti-Mouse TIGIT Rabbit Recombinant Antibody (CL750-98026, Clone: 240242G1) (black, dashed). Cells were not fixed.
Product Details
CL750-98026
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240242G1
Immunogen
Fusion Protein
Conjugate
Excitation/Emission Max
755/780 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-cell immunoreceptor with Ig and ITIM domains; tigit; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3
Gene Aliases: ENSMUSG00000071552; Vstm3
Entrez Gene ID: (Mouse) 100043314
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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