Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for human CLIC1. BLAST analysis was used to suggest cross-reactivity with CLIC1 from human sources based on 100% homology with the immunizing sequence, 98% homology with rat and mouse, and 97% homology with bovine and Oryctolagus cuniculus. Cross-reactivity with CLIC1 from other sources has not been determined.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Chloride channel ABP; Chloride intracellular channel protein 1; DADB-110M10.1; FLJ94671; hRNCC; NCC27; Nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; Regulatory nuclear chloride ion channel protein; RNCC protein
Gene Aliases: CLIC1; G6; NCC27
UniProt ID: (Human) O00299
Entrez Gene ID: (Human) 1192
Molecular Function: RNA binding protein cytoskeletal protein epimerase/racemase isomerase nucleic acid binding oxidoreductase reductase signaling molecule transferase translation elongation factor translation factor