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CPS1 Polyclonal Antibody
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FIGURE: 1 / 1
CPS1 Antibody (BS-14034R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CPS1 Polyclonal Antibody, Unconjugated (bs-14034R) at 1:400 overnight at 4°C, DAB staining.
Product Details
BS-14034R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CPS1, amino acids 1351-1500.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carbamoyl-phosphate synthase (ammonia); carbamoyl-phosphate synthase 1, mitochondrial; Carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1, mitochondrial; Carbamoyl-phosphate synthetase I; carbamoylphosphate synthetase I; carbamyl phosphate synthetase I; carboamyl-phosphate synthetase 1; CPSase I; CPSI; unnamed protein product
Gene Aliases: 4732433M03Rik; CPS; CPS1; CPSASE1; D1Ucla3; GATD6; PHN
UniProt ID: (Human) P31327, (Mouse) Q8C196, (Rat) P07756
Entrez Gene ID: (Human) 1373, (Mouse) 227231, (Rat) 497840
nucleotide binding
catalytic activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
endopeptidase activity
calcium ion binding
protein binding
ATP binding
phospholipid binding
glutamate binding
ligase activity
potassium ion binding
small molecule binding
macromolecular complex binding
metal ion binding
modified amino acid binding
protein complex binding
ligase
urea cycle
liver development
'de novo' pyrimidine nucleobase biosynthetic process
glutamine metabolic process
midgut development
response to xenobiotic stimulus
response to toxic substance
response to zinc ion
response to amine
citrulline biosynthetic process
triglyceride catabolic process
response to food
response to lipopolysaccharide
response to glucagon
response to oleic acid
vasodilation
response to starvation
response to amino acid
cellular response to fibroblast growth factor stimulus
nitric oxide metabolic process
response to steroid hormone
homocysteine metabolic process
response to glucocorticoid
response to cAMP
anion homeostasis
response to growth hormone
hepatocyte differentiation
carbamoyl phosphate biosynthetic process
cellular response to ammonium ion
cellular response to cAMP
cellular response to glucagon stimulus
cellular response to oleic acid
response to dexamethasone
response to alcohol
glycogen catabolic process
proteolysis
arginine biosynthetic process
nitrogen compound metabolic process
metabolic process
positive regulation of vasodilation
glutamine catabolic process
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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