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PD-L1 (B7-H1) Monoclonal Antibody (29E.2A3), Cardinal Red™
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FIGURE: 1 / 2
PD-L1 (B7-H1) Antibody (CR-65081) in Flow
1x10^6 PHA treated (3 days) human PBMCs were surface stained with CL750 Anti-Human CD3 and 5 µL Cardinal Red™ Anti-Human PD-L1 (B7-H1) (CR-65081, Clone: 29E.2A3) (right) or Cardinal Red™ Mouse IgG2b Isotype Control (left). 1x10^6 untreated human PBMCs were surface stained with 5 µL Cardinal Red™ Anti-Human PD-L1 (B7-H1) (CR-65081, Clone: 29E.2A3) (center). Cells were treated with FC Receptor Block prior to staining. Cells were not fixed. Lymphocytes were gated.
Product Details
CR-65081
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
29E.2A3
Immunogen
Full length human PD-L1
Conjugate
Excitation/Emission Max
592/611 nm
Form
Liquid
Concentration
5 µL/Test
Purification
Affinity chromatography
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B7 homolog 1; B7-H1; B7-H1,PD-L1; CD274; CD274 antigen; costimulatory molecule; PD-L1; PDCD1 ligand 1; pdl-1; Programmed cell death 1 ligand 1; programmed death-1 ligand 1; sCD274; similar to Homo sapiens B7-1 and B7-2; soluble CD274; soluble PD L1; soluble PD-L1; B7-H1; sPD L1; unnamed protein product
Gene Aliases: B7-H; B7H1; CD274; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
UniProt ID: (Human) Q9NZQ7
Entrez Gene ID: (Human) 29126
adaptive immune response
immune system process
negative regulation of T cell mediated immune response to tumor cell
immune response
signal transduction
cell surface receptor signaling pathway
T cell costimulation
negative regulation of interferon-gamma production
negative regulation of interleukin-10 production
positive regulation of interleukin-10 production
response to cytokine
TRIF-dependent toll-like receptor signaling pathway
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of transcription, DNA-templated
regulation of activated T cell proliferation
negative regulation of activated T cell proliferation
negative regulation of T cell activation
regulation of T cell apoptotic process
cellular response to lipopolysaccharide
negative regulation of tumor necrosis factor superfamily cytokine production
regulation of activated CD4-positive, alpha-beta T cell apoptotic process
positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process
negative regulation of CD4-positive, alpha-beta T cell proliferation
negative regulation of CD8-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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