This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
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Protein Aliases: bolekine; breast and kidney; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 14; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 14; Chemokine BRAK; CXC; CXC chemokine in breast and kidney; CXC motif chemokine; CXCL; MGC10687; MIP-2 gamma; MIP-2G; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK); Small-inducible cytokine B14; tumor-suppressing chemokine
Gene Aliases: BMAC; BRAK; CXCL14; KEC; KS1; MIP-2g; MIP2G; NJAC; PSEC0212; SCYB14; UNQ240/PRO273
UniProt ID: (Human) O95715
Entrez Gene ID: (Human) 9547